The Types Of Bladder Cancer

November 3, 2021

The bladder is a hollow, sac-like organ in the pelvic area that stores urine before it is excreted. The wall of the bladder has several layers. First, there is a layer of cells lining the inside of the bladder called transitional, or urothelial, cells. Beneath that is a thin layer of connective tissue called the lamina propria. Next is a layer of muscle tissue, and after that is a layer of fatty tissue that separates the bladder from organs next to it.

Where the cancer occurs and what type of cells are involved determines the type of bladder cancer you have.

Bladder Cancer: Know the Different Types

There are four main types of bladder cancer, which are categorized by the way they look under a microscope. Each type of bladder cancer may respond differently to chemotherapy or radiation treatment.

Transitional cell carcinoma, also known as urothelial carcinoma: More than 90 percent of all bladder cancers fall into this category. There are subcategories of transitional cell carcinomas, depending on where the tumor is growing and how much the cancer has spread:
Superficial bladder cancer. When the cancer has stayed in the transitional layer and has not spread to the other layers of the bladder (the connective tissue, the muscles, and beyond), it’s called superficial bladder cancer, or carcinoma in situ. The recurrence rate for this type of cancer is high; it often comes back as another superficial bladder cancer after treatment. “The rate of recurrence for this type of cancer is 60 to 80 percent,” says Jeff Holzbeierlein, MD, associate professor at the University of Kansas Medical Center in Kansas City, Kan. “There are already changes in the lining of the bladder — cell changes have already occurred, so the cancer is still likely to come back.”
Invasive bladder cancer. When a superficial bladder cancer spreads to the deeper layers of the bladder wall, it is called invasive bladder cancer. Cancer that has spread to the muscle tissue and beyond is more serious than invasive cancer that has reached only the connective tissue.
Metastatic bladder cancer. Invasive bladder cancer can spread to nearby organs, such as the uterus or vagina in women and the prostate gland in men. It can enter the lymphatic system and blood vessels, and travel to the liver, lung, bones — any organ in the body.
Squamous cell carcinoma: This type of bladder cancer usually forms after a long-term infection, such as chronic urinary infections, or chronic irritation of the bladder, such as from bladder stones. These infections or irritations can cause transitional cells to change into squamous cells, which are thin, flat cells that are at greater risk of turning into cancer.
Adenocarcinoma: This is a rare but dangerous form of bladder cancer. Only 1 to 3 percent of all bladder cancers are this type, but the tumors tend to be aggressive. Adenocarcinoma can begin primarily in the bladder, but can also originate in the gland cells of other organs, like the lung, stomach, pancreas, liver, or colon, and then spread to the bladder.
Small cell bladder cancer: This is a rare form of bladder cancer, accounting for 1 to 2 percent of all bladder cancers. It can also originate elsewhere, such as in the lungs, and is a dangerous form of bladder cancer. “It’s usually metastatic (has spread outside of the bladder),” says Dr. Holzbeierlein. “We usually start with chemotherapy.”
Bladder Cancer: Stage, Prognosis, and Recurrence Rates

Once the type of bladder cancer has been determined, the doctor needs to determine how far the cancer has spread. This is called staging. Each stage of cancer has different survival rates.

Stage 0 or I: The cancer is contained; the cancer cells have not grown beyond the inner lining of the bladder (Stage 0) or beyond the layer of tissue supporting the inner lining of the bladder (Stage I). The cancer has not extended into the muscle or out into lymph nodes. The five-year survival rate for Stage 0 bladder cancer is 95 percent while that for Stage I is 85 percent, according to the American Cancer Society.

Stage II: The cancer cells have spread to the muscle layer; this stage of bladder cancer has a five-year survival rate of approximately 55 percent.

Stage III: Cancer has spread outside the bladder to the fat separating the bladder from other organs, resulting in a five-year survival rate of 38 percent.

Stage IV: Cancer cells have spread to other organs, reducing the five-year survival rate to 16 percent.

Bladder cancer is a disease that has a high rate of recurrence, as much as 50 to 80 percent. Because of this high recurrence rate, follow-up for bladder cancer is especially important. Talk to your doctor about your individualized follow-up plan; most experts advise return visits and exams every three to six months.

A diagnosis of bladder cancer can be daunting, but by learning about the types of bladder cancer and discussing the treatment and management options for your specific cancer with your doctor, you can arm yourself for battle against this often-treatable disease.